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Smith Drug Store

About Smith Drug Store

Smith Drug Store is a trusted destination for pharmacy, shopping, and health and wellness needs in Spartanburg, SC. Conveniently located at 142 E Main St, the store offers practical services designed to make managing medications and everyday health needs easier.

Customers can choose delivery, in-store pickup, or on-site services based on what works best for them, while the quick-visit planning option makes it convenient to stop in when time matters.

Smith Drug Store also provides medication disposal, giving customers a convenient place to handle unwanted medications responsibly. Accessibility is an important part of the experience, with a wheelchair-accessible car park, entrance, and toilet available for greater ease and comfort during each visit.

Payment options include credit cards, debit cards, NFC mobile payments, and SNAP/EBT, helping accommodate a range of customer preferences.

With a customer rating of 4.50 out of 5 based on 37 reviews, Smith Drug Store has earned strong feedback from the people it serves. Whether you need pharmacy support, medication disposal, delivery, pickup, or on-site services, Smith Drug Store offers a convenient and accessible choice in the Spartanburg community.

For more information, call +1 864-583-4521.

★★★★★ 4.50 rating (37 reviews)
Smith Drug Store
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Quality Products

Carefully curated selection

Expert Staff

Friendly, knowledgeable help

Great Value

Competitive pricing always

Happy Customers

Satisfaction guaranteed

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4.50
Star Rating
37+
Happy Customers

Customer Reviews

What shoppers say about us

dawn licha

dawn licha

3 years ago

Best pharmacy I have ever used. They are super friendly and very knowledgeable

Emily Grace

Emily Grace

3 years ago

I’ll never use another pharmacy. They are so friendly & caring. 💞 Thank you Smiths Drugstore!! …

Darlyn Lollis

Darlyn Lollis

2 years ago

Been going here for prescriptions for years. Very patient and informative, helped me clear up all types of confusion I had. Excellent service. Highly recommend!

John Hines

John Hines

3 years ago

I have no words to describe how much better this pharmacy is especially compared to ANY other in town no comparison. I'd drive an hour out of my way, Walgreens etc well they can't even compete. The manager is a good and fair man

Pat Patel

Pat Patel

2 years ago

Spoke with Pharmacist. Very knowledgeable and friendly staff. Went out on his way to help out visiting patient in the area and wanting to makes sure his patients were taken care of! Highly Recommend. Dr K and his team!!

Ryan _

Ryan _

3 years ago

I’d forgotten what it was like to have pharmacists that show that additional level of care and attentiveness before I started using Smith Drug Store. Since I started using Smith last year, it’s been a pleasure. They’re easy to get ahold of on the phone, they work with my schedule, and their level of consultation is excellent.

Anna Johnson

Anna Johnson

2 years ago

Very thankful for their help finding and filling a prescription at the last minute for my daughter last week. Definitely went beyond what they had to do to help me get it filled before the weekend. Will be having all future scripts filled here.

Tanna Thompson

Tanna Thompson

2 years ago

I love this pharmacy! Great pharmacists & staff. They’re able to order some of my harder-to-get meds that the big box stores can’t seem to get in stock or care to. I really appreciate how they continually go above & beyond!

Meta m Griffin

Meta m Griffin

year ago

The pharmacy has given me good advice about allergy and decongestant medications. Other pharmacies don’t have the time to do so. I am considering transferring my prescriptions.

Charles Thornton

Charles Thornton

2 years ago

Really good folks, the kind that actually cares about you and your needs, they get your meds ready fast, and if they don't have the Rx they will get it the same day or next morning, they make sure you have refill s if not they will call the doctor for you if you want. most of all, great people, friendly, very caring and ready to answer all of your questions with a smile and a thank you.

Frequently Asked Questions

Common questions about Smith Drug Store

Business Features

Highlights & Amenities

Accessibility

  • Wheelchair-accessible car park
  • Wheelchair-accessible entrance
  • Wheelchair-accessible toilet

From the business

  • Small Business

Service options

  • Delivery
  • In-store pick-up
  • On-site services

Offerings

  • Medication disposal

Planning

  • Quick visit

Payments

  • Credit cards
  • Debit cards
  • NFC mobile payments
  • SNAP/EBT

Parking

  • Free parking lot
  • Free street parking

Visit Our Store

Stop by and see us. We'd love to help you find what you're looking for.

Location

142 E Main St, Spartanburg, SC 29306, United States

Store Hours

Closed · Wednesday 8:30 AM-6 PM
Saturday 8:30 AM-2 PM
Sunday Closed
Monday 8:30 AM-6 PM
Tuesday 8:30 AM-6 PM
Wednesday 8:30 AM-6 PM
Thursday 8:30 AM-6 PM
Friday 8:30 AM-6 PM
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